[ad_1]
An anti-inflammatory drug normally used to treat rheumatoid arthritis reduces the risk of death when given to hospitalised patients with severe Covid-19, according to a study led by researchers at the University of Oxford.
The benefit of baricitinib is in addition to those of dexamethasone and tocilizumab, two other anti-inflammatory treatments which have previously been shown to reduce the risk of death in these patients, the researchers said.
“It is now well-established that in people admitted to hospital because of severe Covid-19, an over-active immune response is a key driver of lung damage,” said Sir Martin Landray, a professor at Oxford Population Health, and joint chief investigator for the trial.
“The results not only show that treatment with baricitinib improves the chances of survival for patients with severe Covid-19, but that this benefit is additional to that from other treatments that dampen down the over-active immune response, such as dexamethasone and tocilizumab,” Landray said.
The yet-to-be peer-reviewed finding, posted recently on preprint repository MedRxiv, opens up the possibility of using combinations of anti-inflammatory drugs to further drive down the risk of death for some of the sickest patients.
The Oxford-led Randomised Evaluation of Covid-19 Therapy (RECOVERY) trial has been testing a range of potential treatments for patients admitted to hospital for Covid-19 since March 2020.
The researchers randomly allocated 4,008 patients to usual care alone compared with 4,148 patients who were randomly allocated to usual care plus baricitinib.
The dose of baricitinib tablets was 4 milligrammes (mg) once daily for 10 days.
At randomisation, 95 per cent of patients were receiving a corticosteroid such as dexamethasone, 23 per cent were receiving tocilizumab, and 20 per cent were receiving the anti-viral drug remdesivir.
Two-thirds of patients were receiving oxygen and one quarter were receiving additional respiratory support, the researchers said.
Treatment with baricitinib significantly reduced deaths: 513 of the patients in the baricitinib group died within 28 days compared with 546 patients in the usual care group, a reduction of 13 per cent, they said.
The benefit of baricitinib was consistent regardless of which other Covid-19 treatments the patients were also receiving, including corticosteroids, tocilizumab, or remdesivir.
Patients receiving baricitinib were also more likely to be discharged alive within 28 days, according to the researchers.
Among patients not on invasive mechanical ventilation when entered into the trial, baricitinib reduced the chance of progressing to invasive mechanical ventilation or death from 17 per cent to 16 per cent, they said.
There was no evidence that the short course of baricitinib used in the trial increased the risk of other infections or of blood clotting complications.
The study considerably strengthens the evidence from earlier trials that baricitinib is beneficial in severe Covid-19, and provides new evidence of the additional benefit of baricitinib on top of other immunomodulatory treatments.
The RECOVERY trial is twice as large as the eight previous trials of baricitinib and similar drugs for the treatment of Covid-19 combined, the researchers said.
Overall the nine trials, which involved about 12,000 patients, found that the use of baricitinib reduced deaths in patients hospitalised for Covid-19 by about one-fifth, they said.
“This result confirms and extends earlier findings, providing greater certainty that baricitinib is beneficial and new data to guide the treatment of Covid-19 patients with a combination of drugs to dampen the immune response,” said Sir Peter Horby, a professor at the University of Oxford, and joint chief investigator for RECOVERY.
“As always, the next challenge is ensuring this and other Covid-19 treatments are available and affordable for everyone who can benefit, regardless of where they live,” Horby said.
Follow more stories on <strong>Facebook </strong>and <strong>Twitter</strong>
This story has been published from a wire agency feed without modifications to the text. Only the headline has been changed.
[ad_2]
Source link
This is for easy to reach lumps or those that might be filled with fluid priligy dosage This may reflect the longer stimulus used for TRAPing 4 hr, versus 1 hr for Fos immunostaining or some general noise in the TRAP approach
allergy pills for rash prescription only allergy medication walgreen generic allergy pills
prednisone 10mg over the counter order prednisone sale
over the counter medication that causes nausea order lamivudine 100 mg generic
dermatologist recommended acne products buy cleocin 300mg pill popular prescription acne medication
claritin allergy sinus 12hr costco order zaditor 1mg for sale alternatives to allergy pills
best otc treatment for nausea buy glucophage pill
isotretinoin order online order isotretinoin 10mg online buy isotretinoin sale
strong dangerous sleeping pills cheap phenergan
buy zithromax pills for sale zithromax cheap zithromax 250mg ca
buy gabapentin 100mg online neurontin 800mg without prescription
azithromycin buy online purchase azithromycin generic order azithromycin for sale
purchase furosemide for sale furosemide us
order omnacortil 20mg generic brand prednisolone 5mg omnacortil online
order amoxicillin 500mg amoxil ca order amoxil 250mg sale
order doxycycline without prescription monodox pills
buy augmentin 375mg for sale buy augmentin 375mg sale
order vardenafil generic vardenafil sale
order clomid 50mg pill oral clomiphene 50mg clomiphene 100mg cheap
buy rybelsus pills rybelsus price buy semaglutide paypal
order semaglutide 14mg online generic semaglutide order rybelsus pills
augmentin generic amoxiclav brand buy clavulanate no prescription
order levoxyl pill order synthroid 75mcg generic cheap levothroid sale
buy clomiphene without prescription buy cheap clomiphene clomid price
buy sildenafil 100mg pill order sildenafil 100mg online cheap order viagra 100mg
vardenafil 20mg cost order levitra order levitra 20mg generic
buy pregabalin 75mg generic lyrica canada lyrica 150mg cheap
hydroxychloroquine 400mg canada where to buy plaquenil without a prescription purchase hydroxychloroquine pills
zithromax and sinus infection
purchase desloratadine generic buy clarinex generic clarinex pill
cialis 10mg pill cialis 5mg for sale cialis 10mg price
buy cenforce 50mg generic order cenforce online buy cenforce 50mg online
purchase chloroquine online cheap buy aralen 250mg without prescription buy generic chloroquine 250mg
is metformin bad for your kidneys
buy glucophage 1000mg online glycomet 1000mg cost buy glycomet 1000mg sale
lisinopril starting dose
how much is zoloft without insurance
flagyl for tooth infection
furosemide lasix 20 mg tablet
buy amlodipine 5mg buy amlodipine 5mg sale brand norvasc
gabapentin over the counter
a1c glucophage
buy lisinopril pills for sale lisinopril tablet cost zestril 2.5mg
alcohol zithromax
cefadroxil vs cephalexin
purchase omeprazole generic prilosec oral omeprazole 10mg without prescription
chlamydia amoxicillin
escitalopram for social anxiety
purchase lopressor for sale cheap metoprolol 50mg generic lopressor 50mg
cephalexin warnings
how long should my dog take ciprofloxacin
order tenormin 100mg generic atenolol 50mg canada cheap atenolol 50mg
buy medrol pills methylprednisolone tablets medrol 8mg without a doctor prescription
help with papers help with essays paperwriter
bactrim constipation reddit
can cephalexin treat stds
order mobic generic mobic medication buy celebrex 100mg
what medications should not be taken with bactrim
purchase tamsulosin without prescription tamsulosin 0.2mg oral celecoxib without prescription
escitalopram cost no insurance
gabapentin and benadryl
zofran brand zofran for sale how to get aldactone without a prescription
order simvastatin 10mg online valacyclovir 1000mg for sale valtrex 1000mg usa
depakote 500 mg
ddavp and high blood pressure
cozaar 100mg tab
citalopram generic names
buy cipro 1000mg online cheap – buy generic baycip for sale augmentin over the counter
cipro cost – oral keflex 250mg amoxiclav online order
depakote 125 mg
cozaar merck
bausch & lomb ddavp
flagyl 200mg over the counter – buy generic zithromax azithromycin 500mg for sale
citalopram ansiedad
order ciprofloxacin pill – order tindamax erythromycin 500mg for sale
oral valtrex 500mg – cost acyclovir 400mg generic acyclovir 400mg
diclofenac wiki
augmentin nausea
diltiazem drip for afib
does flexeril get you high
oral metronidazole 200mg – buy azithromycin 250mg generic order zithromax pills
flomax alb
over the counter equivalent to contrave
lasix 40mg generic – atacand 16mg for sale capoten 25 mg cost
aripiprazole qt prolongation
can amitriptyline cause weight gain
cat aspirin
buy glycomet 1000mg generic – order lincocin 500mg for sale purchase lincomycin for sale
allopurinol and gout attack
zidovudine 300mg without prescription – purchase roxithromycin for sale allopurinol over the counter
baclofen medicine
bupropion 150 mg
augmentin 500-125
buy clozapine generic – frumil 5mg canada buy famotidine 40mg online
is celebrex safe for long term use
ashwagandha negative side effects
will buspirone make you gain weight
celexa and klonopin
buy celebrex celecoxib 200 mg
anafranil 50mg cheap – tofranil for sale online sinequan 75mg cheap
order generic hydroxyzine 10mg – order hydroxyzine online cheap order endep
buy generic amoxicillin over the counter – order cefadroxil 500mg ciprofloxacin 500mg generic
buy clavulanate without a prescription – purchase zyvox generic cipro 500mg tablet
fake semaglutide
thuoc acarbose
abilify cost per month
actos reglamentarios+concepto
oral cleocin 150mg – capsules oxytetracycline order chloromycetin for sale
is robaxin 750 a controlled substance
zithromax generic – buy metronidazole online cheap buy ciprofloxacin medication
repaglinide metformin hydrochloride
protonix for ulcer
is remeron addictive
ivermectin order – doryx price where to buy cefaclor without a prescription
buy asthma pills onlin – order theo-24 Cr 400 mg sale brand theo-24 Cr 400mg
purchase desloratadine generic – order zaditor online cheap albuterol for sale
reviews on spironolactone
dosage of sitagliptin
synthroid sinemet
micronase online buy – buy actos pills buy dapagliflozin 10mg sale
venlafaxine with food
voltaren and heart attack
tizanidine pill identifier
generic repaglinide – empagliflozin over the counter buy empagliflozin 10mg generic
glucophage price – cozaar 50mg price buy acarbose generic
doxazosin and tamsulosin
wellbutrin for opiate
pregnant and zofran
what is the drug zyprexa used for
how to get lamisil without a prescription – terbinafine 250mg price order griseofulvin pills
zetia copay card
buy generic rybelsus for sale – desmopressin online desmopressin us
iv dosage for zofran
zyprexa,
buy nizoral for sale – mentax sale sporanox 100 mg cheap
generic famciclovir – cheap zovirax 800mg valaciclovir 1000mg ca
buy digoxin 250 mg without prescription – verapamil 240mg usa buy lasix 100mg sale